THALIDOMIDE DECREASES GELATINASE PRODUCTION BY MALIGNANT B LYMPHOID CELL LINES THROUGH DISRUPTION OF MULTIPLE INTEGRIN-MEDIATED SIGNALING PATHWAYS

Thalidomide decreases gelatinase production by malignant B lymphoid cell lines through disruption of multiple integrin-mediated signaling pathways

Background Thalidomide and its analogs are effective agents in the treatment of multiple myeloma.Since gelatinases (matrix metalloproteinases-2 and -9) play a crucial role in tumor progression, we explored the effect of thalidomide on gelatinase production by malignant B lymphoid cell lines.Design and Methods We investigated the effect of therapeut

read more

Comparison of shear bond strength of self-etching fluoride releasing adhesives with and without pumice prophylaxis

Context: Despite the advances in orthodontic material and treatment mechanics, the placement of fixed appliances increases the risk of enamel demineralization.The development of fluoride release adhesives has attracted considerable interests because the combined use of antimicrobials and fluoride enhances the cariostatic effect.Aim: To compare the

read more